COMMENTS ABOUT POTENTIAL BIOLOGICAL WEAPONS

By Manuel Cereijo

March, 2002

Disease or agent	Lethality, Fatality rate	Delivery methods	Diagnosis	Incubation	Vaccine	Symptoms
Anthrax	100% 20%	Aerosol Direct contact	Non-specific. May see a wide mediastinum on CXR	1-10 days	Yes. Booster yearly	Fever, malaise, cough, severe respiratory distress, shock
Botulism	10%	Ingested Aerosol	Serology/Culture	1-5 days	Pentavalent anti-toxin	Ptosis, Weakness, dizziness, blurred vision, respiratory failure
Cholera	50% If noRx	Drinking Water	Clinical/Darkfield, Culture	4 hrs - 5 days	Yes. Lasts 6 months	Vomiting, intestinal cramps,diarrhea
Glanders	90-100% If not Rx	Aerosol	Sputum culture Miliary lesion on CXR	10-14 days	NONE	Fever,sweats, myalgia,chest pain, diarrhea, pnemonia
Plague	Bubonic 60% Pneumonic 98%	Zoonosis Aerosol	Nasal, Sputum culture, PCR immunoassay	2-3 days	Yes, Bubonic, not aerosol	High fever, chills, headache, toxemia, cyanosis
Tularemia	35% If not Rx	Aerosol	Culture serology	1-10 days	Yes	Local ulcer, fever, headache, cough, prostation
Ricin	100%	Aerosol Ingestion Injection	Protein toxin	8 hrs, death in 36 hours	None	Gastrointestinal hemorrhage, necrosis, fever, cough
Small Pox	35%	Aerosol	PCR	7-19 days	Yes. Not available for mass use	Fever, malaise, vomiting,
T-2Mycotoxins	100%	Aerosol, contact,ingestion	Blood Toxicology	Death in minutes, hours	NONE	Pruritus, necrosis, dyspnea, hemoptysis, bone marrow collapse
Viral Hemmorrhagic Fever	Ebola, Marburg, Rift Valley 90%	Several methods	Viral isolation	Varies with type, Few hours	Only for Yellow Fever	Bleeding, vomiting, microvascular damage

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